Amlodipine besylate is a drug that is used for treating high blood pressure, certain types of angina, and coronary heart failure. One of the major problems with this drug is its low solubility in biological fluids, which results into poor bioavailability after oral administration. The purpose of the present investigation was to increase the solubility and dissolution rate of amlodipine besylate by the preparation of its solid dispersion with polyethylene glycol 4000, polyethylene glycol 6000 & polyvinyl pyrrolidine k30 by using solvent evaporation method in the 1:1, 1:3 and 1:5 ratios of drug and carrier respectively. The prepared solid dispersions were characterized by IR spectroscopy & DSC suggested no interaction of drug with carriers. The solid dispersions were evaluated for physical appearance, % practical yield, drug entrapment efficiency, solubility & in-vitro dissolution. All the Solid Dispersions Prepared Were Found to be Fine Free Flowing Powder. The drug entrapment efficiency of the prepared Solid dispersions were in the range of 89.3% - 97% indicated that the drug is uniformly dispersed in the powder formulation. The solubility of amlodipine besylate was increased with increase in conc. of carrier for all the solid dispersions. Among the carriers used, PVP K-30 showed highest solubility in the range of 2.21 to 2.69 mg/ml. Dissolution rate of solid dispersion was determined in 0.01 N HCl at 75 rpm. At the end of 60 min, formulation F2 gave the highest drug release that is 95.02%. Kinetic study mainly revealed that the drug releases from the solid dispersions follow zero order kinetics.
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